N-Methylbutylamine → Acetamide, 2-bromo-N-butyl-N-methyl-

To a solution cooled to -20° C. of 11.9 ml of bromoacetyl bromide in 180 ml of ether there were added 26 g of butylmethylamine in solution in 120 ml of ether and then the temperature returned to 20° C. The mixture was stirred for 30 minutes and diluted with water and extracted with ether. The ether phase was evaporated to dryness under reduced pressure and the 27.4 g of residue were distilled under reduced pressure (0.05 mbar) at 79/83° C. to obtain 19.36 g of the desired product.

1. customreturned to 20° C
2. extractionextracted with ether
3. customThe ether phase was evaporated to dryness under reduced pressure
4. distillationthe 27.4 g of residue were distilled under reduced pressure (0.05 mbar) at 79/83° C.

ORDレコード

ord-303aa417d5f94188a1ecbb0c9b677fd8

出典データセット

uspto-grants-1994_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05290771