Water → HCID 178441853、化合物

HRID 486621ノート

反応式

HRID 486621 の反応式
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10](I)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].[Cu][C:18]#[N:19].O>N1C=CC=CC=1>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:18]#[N:19])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]

参加物

5

反応物 3

HCID 962WaterHCID 178418546HCID 178418546、化合物HCID 178441862HCID 178441862、化合物

生成物 1

HCID 178441853HCID 178441853、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A mixture of 6.4 g of 2-butyl-6-iodo-4(1H)-quinazolinone in 25 ml of pyridine is added 3.6 g of copper(I) cyanide followed by heating at reflux for 16 hours. The reaction mixture is poured into water and stirred at room temperature for 8 hours. The suspension is filtered and the cake washed well with water and air dried. The solid is dissolved in 3:1 chloroform-methanol and dried with MgSO4. The volatiles are evaporated in vacuo to give 3.2 g of the desired pro-duct as a solid. m.p. 243°-45° C.

後処理

  1. temperatureby heating
  2. temperatureat reflux for 16 hours
  3. filtrationThe suspension is filtered
  4. washthe cake washed well with water and air
  5. customdried
  6. dissolutionThe solid is dissolved in 3:1 chloroform-methanol
  7. dry with materialdried with MgSO4
  8. customThe volatiles are evaporated in vacuo
  9. customto give 3.2 g of the

出典と根拠

ORDレコード
ord-79fc4ab865b54047a5aa4e1557c3feda
出典データセット
uspto-grants-1994_03
特許番号
US05292742

反応ノート

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