HCID 15062404、化合物 → HCID 22556038、化合物

HRID 486851ノート

反応式

HRID 486851 の反応式
[Cl:1][CH2:2][CH:3]1[O:8][C:7](=[O:9])[CH2:6][C:5](=[O:10])[CH2:4]1>[Pt](=O)=O.C(OCC)(=O)C>[Cl:1][CH2:2][CH:3]1[O:8][C:7](=[O:9])[CH2:6][CH:5]([OH:10])[CH2:4]1

参加物

4

反応物 1

HCID 15062404HCID 15062404、化合物

生成物 1

HCID 22556038HCID 22556038、化合物収率 73.1%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 270 mg (1.66 mmol) of (-)-6-chloromethyltetrahydropyran-2,4-dione obtained in Example 1, 10 mg platinum dioxide and 100 ml of ethyl acetate was stirred for 7 hours under hydrogen atmosphere. After completion of the reaction, the catalyst was removed by filtration, and the solvent was distilled off to obtain 199.6 mg (yield 73%) of (+)-6-chloromethyl-4-hydroxytetrahydropyran-2-one [a compound of the formula (3)] having

後処理

  1. customAfter completion of the reaction
  2. customthe catalyst was removed by filtration
  3. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-130855e80373404da6f02c2baf9f0a92
出典データセット
uspto-grants-1994_03
特許番号
US05292891

反応ノート

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