Acetic Acid → HCID 15170719、化合物

HRID 486883

反応式

HRID 486883 の反応式
[SH:1][C:2]([CH3:13])([CH3:12])[C:3]([NH:5][C@H:6]([C:9]([OH:11])=[O:10])[CH2:7][SH:8])=[O:4].[C:14](O)(=O)C>CCOCC.[N+](=C)=[N-]>[CH3:14][O:10][C:9](=[O:11])[C@H:6]([CH2:7][SH:8])[NH:5][C:3](=[O:4])[C:2]([SH:1])([CH3:13])[CH3:12]

参加物

5

反応物 2

HCID 176Acetic AcidHCID 656604Bucillamine

生成物 1

HCID 15170719HCID 15170719、化合物収率 94%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒2 回HCID 9550Diazomethane溶媒

実験手順

To a solution of N-(2-mercapto-2-methylpropionyl)-L-cysteine (1.0 g) in ether(3 ml), diazomethane dissolved in ether(12 ml) was added dropwise under ice-cooling. After the addition, acetic acid was added to the reaction mixture. The reaction mixture was washed with saturated sodium hydrogen carbonate solution and saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo. The oily residue was purified by a silica gel column chromatography to give 1.0 g(94%) of the titled compound.

後処理

  1. additionwas added dropwise under ice-
  2. temperaturecooling
  3. additionwas added to the reaction mixture
  4. washThe reaction mixture was washed with saturated sodium hydrogen carbonate solution and saturated sodium chloride solution
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated in vacuo
  7. customThe oily residue was purified by a silica gel column chromatography

出典と根拠

ORDレコード
ord-d22ad1ba57f24a5b9ffc12e56b23c69d
出典データセット
uspto-grants-1994_03
特許番号
US05292926

関連ノート

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