Water → 2-(Benzo[d][1,3]dioxol-5-yl)propan-2-ol

HRID 486888

反応式

HRID 486888 の反応式
[CH3:1][Li].[C:3]([C:6]1[CH:14]=[CH:13][C:9]2[O:10][CH2:11][O:12][C:8]=2[CH:7]=1)(=[O:5])[CH3:4].O>O1CCCC1>[O:10]1[C:9]2[CH:13]=[CH:14][C:6]([C:3]([OH:5])([CH3:1])[CH3:4])=[CH:7][C:8]=2[O:12][CH2:11]1

参加物

5

反応物 3

HCID 962WaterHCID 76622AcetopiperoneHCID 178418348HCID 178418348、化合物

生成物 1

HCID 118196322-(Benzo[d][1,3]dioxol-5-yl)propan-2-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
-20 °C

実験手順

About 600 ml of 1.5M methyllithium (solution in ether) was added to 500 ml of tetrahydrofuran. A suspension of 93.45 g of 5-acetyl-1,3-benzodioxole in 900 ml of tetrahydrofuran was added thereto under cooling at -20° C. The mixture was stirred under these conditions for 1 h. Water was added to the reaction mixture. The product was extracted with ethyl acetate, washed with a saturated aqueous common salt solution and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated to obtain 97 g of the intended compound in the form of an oil.

後処理

  1. additionwas added
  2. extractionThe product was extracted with ethyl acetate
  3. washwashed with a saturated aqueous common salt solution
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationAfter filtration
  6. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-d359b559f57a4cdc9504feb94d8a3821
出典データセット
uspto-grants-1994_03
特許番号
US05292901

関連ノート

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