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1,5-Dibromopentane → 2-(N-Benzyloxycarbonylamino)-3-[4-(5-bromopentyloxy)phenyl]propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,5-Dibromopentane | HCID 8100 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | N-benzyloxycarbonyl-l-tyrosine | HCID 712438 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(N-Benzyloxycarbonylamino)-3-[4-(5-bromopentyloxy)phenyl]propionic acid | HCID 19093599 | 24.3% |
反応手順
N-CBZ-L-tyrosine (2.06 g, 5.86 mmole) was treated with NaH (0.58 g, 12.08 mmole) and 1,5-dibromopentane (0.8 ml, 5.87 mmole) as described for 1-1 in Example 1. The crude product was dissolved in methanol and after stirring with silica gel for 0.5 hour, the solvent was removed. This was dry packed and eluted on a flash column with CHCl3 and then with 97:3:0.3 CHCl3 /CH3OH/HOAc to give pure 1-10 (0.66 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05294616 |
| 出典データセット | uspto-grants-1994_03 |
| ORD ID | ord-e10905b762ca442ba579938f67ff9895 |
| 出典メモ | uspto-grants-1994_03 |