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HRID487093

反应详情

EQUATION

反应方程式

HRID 487093 的结构方程式

REACTANTS

反应物

3
结构：BrCCCCCBr
HCID8100

1,5-Dibromopentane

C5H10Br2

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)OCc1ccccc1
HCID712438

Carbobenzoxy-L-tyrosine

C17H17NO5

PRODUCTS

生成物

1
结构：O=C(NC(Cc1ccc(OCCCCCBr)cc1)C(=O)O)OCc1ccccc1
HCID19093599

未命名化合物

收率 24.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

N-CBZ-L-tyrosine (2.06 g, 5.86 mmole) was treated with NaH (0.58 g, 12.08 mmole) and 1,5-dibromopentane (0.8 ml, 5.87 mmole) as described for 1-1 in Example 1. The crude product was dissolved in methanol and after stirring with silica gel for 0.5 hour, the solvent was removed. This was dry packed and eluted on a flash column with CHCl3 and then with 97:3:0.3 CHCl3 /CH3OH/HOAc to give pure 1-10 (0.66 g).

WORKUP

后处理

  1. customthe solvent was removed
  2. customThis was dry
  3. washeluted on a flash column with CHCl3