Sodium → 1-cyclopentyl-3-ethyl-6-imidazo[1,2-a]pyridin-6-yl-2H-pyrazolo[3,4-d]pyrimidin-4-one

HRID 487268

反応式

HRID 487268 の反応式
[Na].[C:2]([C:7]1[CH:8]=[CH:9][C:10]2[N:11]([CH:13]=[CH:14][N:15]=2)[CH:12]=1)(OCC)=O.[CH:16]1([N:21]2[C:25]([NH2:26])=[C:24]([C:27]([NH2:29])=[O:28])[C:23]([CH2:30][CH3:31])=[N:22]2)[CH2:20][CH2:19][CH2:18][CH2:17]1>C(O)C>[CH:16]1([N:21]2[C:25]3=[N:26][C:2]([C:7]4[CH:8]=[CH:9][C:10]5[N:11]([CH:13]=[CH:14][N:15]=5)[CH:12]=4)=[N:29][C:27](=[O:28])[C:24]3=[C:23]([CH2:30][CH3:31])[NH:22]2)[CH2:17][CH2:18][CH2:19][CH2:20]1

参加物

5

反応物 3

HCID 5360545SodiumHCID 11830209Ethyl imidazo[1,2-a]pyridine-6-carboxylateHCID 224493525-amino-1-cyclopentyl-3-ethyl-1H-pyrazole-4-carboxamide

生成物 1

HCID 1784378341-cyclopentyl-3-ethyl-6-imidazo[1,2-a]pyridin-6-yl-2H-pyrazolo[3,4-d]pyrimidin-4-one収率 62%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium metal (0.21 g, 9.2 mmol) was dissolved in ethanol (25 ml) and 6-carboethoxyimidazo[1,2-a]pyridine (1.75 g, 9.2 mmol) and 1-cyclopentyl-3-ethyl-5-amino-1H-pyrazole-4-carboxamide (1.02 g, 4.6 mmol) were added. The reaction mixture was heated to reflux for 24 hours, cooled to room temperature and stirred for 60 hours. The solvent was removed in vacuo, the residue was dissolved in water (100 ml) and the solution was neutralized by the addition of concentrated HCl. A precipitate was obtained which was collected by filtration through a glass frit. The solid was recrystallized from ethanol and washed with ether to afford 0.98 g (62%) of 1-cyclopentyl-3-ethyl-6-(6-imidazo[1,2-a]pyridinyl)-pyrazolo[3,4-d]pyrimidin-4-one as white crystals, m.p. >300° C. when dried for 18 hours at 120° C. in high vacuum.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 24 hours
  3. customThe solvent was removed in vacuo
  4. dissolutionthe residue was dissolved in water (100 ml)
  5. additionthe solution was neutralized by the addition of concentrated HCl
  6. customA precipitate was obtained which
  7. filtrationwas collected by filtration through a glass frit
  8. customThe solid was recrystallized from ethanol
  9. washwashed with ether

出典と根拠

ORDレコード
ord-19b4b463815840d1850298edd2de8c12
出典データセット
uspto-grants-1994_03
特許番号
US05294612

関連ノート

読み込み中…