HCID 54132369、化合物 → 6-(4-Hydroxypiperidino)-3,4-dihydrocarbostyril
反応式
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[CH:10][C:11]([N+:21]([O-])=O)=[C:12]([CH:20]=2)[CH:13]=[CH:14][C:15](OCC)=[O:16])[CH2:4][CH2:3]1>[Pd].C(O)(=O)C>[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:20]=[C:12]3[C:11](=[CH:10][CH:9]=2)[NH:21][C:15](=[O:16])[CH2:14][CH2:13]3)[CH2:4][CH2:3]1参加物
4
反応条件
- 温度
- 50 °C
実験手順
A suspension of 5.2 g of ethyl 5-(4-hydroxypiperidino)-2-nitrocinnamate and 1 g of 5% palladium on carbon in 50 ml of acetic acid was stirred under a hydrogen atmosphere at 50° C. for 14 hr. The catalyst was filtrated off and the filtrate was concentrated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography and recrystallized from ethanol to give 1.9 g of 6-(4-hydroxypiperidino)-3,4-dihydrocarbostyril.