Formaldehyde → Butanal, 2-methylene-4-(phenylmethoxy)-

HRID 487472

反応式

HRID 487472 の反応式
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH:12]=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[CH3:15][NH2+]C.C=O>>[CH2:1]([O:8][CH2:9][CH2:10][C:11](=[CH2:15])[CH:12]=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 712FormaldehydeHCID 2315594-BenzyloxybutanalHCID 12954980Dimethylazanium;chloride

生成物 1

HCID 10932234Butanal, 2-methylene-4-(phenylmethoxy)-

実験手順

8.0 g (44.9 mmol) of 4-benzyloxybutanal, 4.12 g (50.6 mmol) of dimethylammonium chloride and 3.95 ml (52.6 mmol) of 37% formaldehyde solution are kept at a bath temperature of 110° for one hour with stirring. The mixture is allowed to cool and is extracted three times with ether. The organic phases are washed with saturated sodium chloride solution, combined, dried over MgSO4, filtered and concentrated by evaporation. 4-benzyloxy-2-methylenebutanal is obtained in the form of a yellowish oil which can be reacted further without further purification.

後処理

  1. temperatureto cool
  2. extractionis extracted three times with ether
  3. washThe organic phases are washed with saturated sodium chloride solution
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-b9de7252a8154654ba4bb616359c0051
出典データセット
uspto-grants-1994_03
特許番号
US05294734

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