Toluene → 4-Ethoxycarbonylmethoxybutyric acid chloride
反応式
[CH2:1]([O:3][C:4]([CH2:6][O:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=O)=[O:5])[CH3:2].C1(C)C=CC=CC=1.C(Cl)(=O)C([Cl:24])=O>CN(C)C=O>[CH2:1]([O:3][C:4]([CH2:6][O:7][CH2:8][CH2:9][CH2:10][C:11]([Cl:24])=[O:13])=[O:5])[CH3:2]参加物
5
反応条件
- 温度
- 50 °C
実験手順
36 g (0.19 mol) of 4-ethoxycarbonylmethoxybutyric acid are charged to 180 ml of toluene and 0.1 ml of dimethyl formamide is added. Then 24.4 ml (0.28 mol) of oxalyl chloride are added dropwise over 30 minutes. When the addition is complete, the reaction mixture is heated to 50° C., stirred for 1 hour and concentrated by evaporation. Distillation of the residue gives 4-ethoxycarbonylmethoxybutyric acid chloride as a clear colourless liquid of b.p. 87°-89° C./2.10-2 torr.
後処理
- additionis added
- additionWhen the addition
- concentrationconcentrated by evaporation
- distillationDistillation of the residue
出典と根拠
- ORDレコード
- ord-d3a0c92a93c04f968a9d7f48ee15fbac
- 出典データセット
- uspto-grants-1994_03
- 特許番号
- US05294734
反応ノート
読み込み中…