Formaldehyde → 4-Acetoxy-2-methylene-pentanal

HRID 487502ノート

反応式

HRID 487502 の反応式
[C:1]([O:4][CH:5]([CH3:10])[CH2:6][CH2:7][CH:8]=[O:9])(=[O:3])[CH3:2].[Cl-].[CH3:12][NH2+]C.C=O>>[C:1]([O:4][CH:5]([CH3:10])[CH2:6][C:7](=[CH2:12])[CH:8]=[O:9])(=[O:3])[CH3:2]

参加物

4

反応物 3

HCID 712FormaldehydeHCID 111054874-AcetoxypentanalHCID 12954980Dimethylazanium;chloride

生成物 1

HCID 189915204-Acetoxy-2-methylene-pentanal収率 93.9%

実験手順

18.0 g (124.8 mmol) of 4-acetoxypentanal, 11.5 g (140.7 mmol) of dimethylammonium chloride and 11.0 ml (146 mmol) of a 37% solution of formaldehyde are stirred for 1 hour at a bath temperature of 110° C. The reaction mixture is allowed to cool and then extracted three times with CH2Cl2. The combined organic phases are dried over MgSO4, filtered and concentrated by evaporation, giving 18.3 g of 4-acetoxy-2-methylene-pentanal as a colourless oil which is further reacted without purification.

後処理

  1. temperatureto cool
  2. extractionextracted three times with CH2Cl2
  3. dry with materialThe combined organic phases are dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-47ad611dbab74bd4bdf5fa0387482c46
出典データセット
uspto-grants-1994_03
特許番号
US05294734

反応ノート

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