Benzocaine → Ethyl 4-(2,5-dimethyl-1H-pyrrol-1-yl)benzoate

HRID 487525ノート

反応式

HRID 487525 の反応式
[CH2:1]([O:3][C:4]([C:6]1[CH:12]=[CH:11][C:9]([NH2:10])=[CH:8][CH:7]=1)=[O:5])[CH3:2].[CH2:13]([CH2:17][C:18](=O)[CH3:19])[C:14]([CH3:16])=O>S(=O)(=O)(O)O.C(OCC)(=O)C>[CH2:1]([O:3][C:4]([C:6]1[CH:12]=[CH:11][C:9]([N:10]2[C:18]([CH3:19])=[CH:17][CH:13]=[C:14]2[CH3:16])=[CH:8][CH:7]=1)=[O:5])[CH3:2]

参加物

5

反応物 2

HCID 2337BenzocaineHCID 80352,5-Hexanedione

生成物 1

HCID 702059Ethyl 4-(2,5-dimethyl-1H-pyrrol-1-yl)benzoate

試薬・触媒・溶媒 2

HCID 1118Sulfuric Acid触媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
150 °C

実験手順

A mixture of 4-ethoxycarbonylaniline (82.6 g), acetonylacetone (68.5 g) and concentrated sulfuric acid (one drop) were heated at 150° C. for one hour. The reaction mixture was diluted with ethyl acetate and washed with water, followed by drying and concentrating, whereby 1-(4-ethoxycarbonylphenyl)-2,5-dimethylpyrrole was obtained.

後処理

  1. washwashed with water
  2. customby drying
  3. concentrationconcentrating

出典と根拠

ORDレコード
ord-a10ef2ba104c469b8c46bd7bde4a3067
出典データセット
uspto-grants-1994_03
特許番号
US05296344

反応ノート

読み込み中…