Dimethyl Sulfoxide → Benzeneethanamine, N-phenyl-

HRID 487585

反応式

HRID 487585 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:8](Br)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+].CS(C)=O>O>[C:10]1([CH2:9][CH2:8][NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 6115AnilineHCID 7666Phenethyl bromideHCID 11430Potassium Carbonate

生成物 1

HCID 74443Benzeneethanamine, N-phenyl-

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of aniline (9.1 ml, 100 mmol), phenethylbromide 18.5 g, 100 mmol), potassiumcarbonate (13.8 g, 100 mmol) and 50 ml dimethylsulfoxide is stirred at ambient temperature for 72 hours, and is diluted with 200 ml water. The mixture is extracted three times with diethylether and the combined organic phases is washed with water and brine and dried over magnesium sulphate. The solution is concentrated in vacuo and the crude product is subjected to a vacuum distillation yielding the title compound as a colourless oil dest. 120°-128° C./0.7 mbar.

後処理

  1. extractionThe mixture is extracted three times with diethylether
  2. washthe combined organic phases is washed with water and brine
  3. dry with materialdried over magnesium sulphate
  4. concentrationThe solution is concentrated in vacuo
  5. distillationthe crude product is subjected to a vacuum distillation

出典と根拠

ORDレコード
ord-67c4a37d41c44531ba33590a77173983
出典データセット
uspto-grants-1994_03
特許番号
US05296493

関連ノート

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