Thionyl Chloride → 1-benzyl-2-(chloromethyl)-1H-imidazole hydrochloride

HRID 487587

反応式

HRID 487587 の反応式
[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[CH2:13]O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>C(Cl)Cl>[ClH:17].[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[CH2:13][Cl:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 311778(1-benzyl-1H-imidazol-2-yl)methanol

生成物 1

HCID 27792431-benzyl-2-(chloromethyl)-1H-imidazole hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 1-benzyl-2-hydroxymethyl-imidazole (6 g, 32 mmol) in methylenechloride is slowly added thionylchloride (3.5 ml, 48 mmol) and after stirring at ambient temperature for 4 hours the reaction mixture is concentrated in vacuo yielding 1-benzyl-2-chloromethyl-imidazole, hydrochloride.

後処理

  1. concentrationis concentrated in vacuo

出典と根拠

ORDレコード
ord-bcd326844a504e529e1c11e39bf5243e
出典データセット
uspto-grants-1994_03
特許番号
US05296493

関連ノート

読み込み中…