Hydrochloric Acid → 4-Tert-butyl-2-[5-(2-carboxyphenylmethoxy)benzofuran-2-yl]thiazole

HRID 487684ノート

反応式

HRID 487684 の反応式
[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[C:27]([O:29]C)=[O:28])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>CO.O>[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[C:27]([OH:29])=[O:28])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 190927604-Tert-butyl-2-[5-(2-methoxycarbonylphenylmethoxy)benzofuran-2-yl]thiazole

生成物 1

HCID 190927584-Tert-butyl-2-[5-(2-carboxyphenylmethoxy)benzofuran-2-yl]thiazole収率 99.7%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A mixture of 4-tert-butyl-2-[5-(2-methoxycarbonylphenylmethoxy)benzofuran-2-yl]thiazole (0.28 g) and 4N aqueous sodium hydroxide (1.0 ml) in methanol (5 ml) was stirred under reflux 5.5 hours. After being cooled, the resulting solution was concentrated under reduced pressure to give a residue. The residue was dissolved in water and adjusted to pH 4 with diluted aqueous hydrochloric acid to give crystals. The crystals were filtered and washed with water to give 4-tert-butyl-2-[5-(2-carboxyphenylmethoxy)benzofuran-2-yl]thiazole (0.27 g).

後処理

  1. temperatureunder reflux 5.5 hours
  2. temperatureAfter being cooled
  3. concentrationthe resulting solution was concentrated under reduced pressure
  4. customto give a residue
  5. customto give crystals
  6. filtrationThe crystals were filtered
  7. washwashed with water

出典と根拠

ORDレコード
ord-18c47e5cef6e4ad7b27097a6505279fd
出典データセット
uspto-grants-1994_03
特許番号
US05296495

反応ノート

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