Hydrochloric Acid → 3-Amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid

HRID 487724ノート

反応式

HRID 487724 の反応式
[OH-].[Na+].C([N:6]1[CH2:11][CH2:10][C:9]2[S:12][C:13]([C:16]([O:18]C)=[O:17])=[C:14]([NH2:15])[C:8]=2[CH2:7]1)(=O)C.Cl>O>[NH2:15][C:14]1[C:8]2[CH2:7][NH:6][CH2:11][CH2:10][C:9]=2[S:12][C:13]=1[C:16]([OH:18])=[O:17]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19093041HCID 19093041、化合物

生成物 1

HCID 190930483-Amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid収率 38%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

An aqueous solution obtained by dissolving 9.1 g of sodium hydroxide in 90 ml of water was added to 5.8 g (46%) of methyl 5-acetyl-3-amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2carboxylate (Compound No. 16) obtained in Example 1 and the resultant mixture was heated under reflux for 2 hours. After cooling followed by neutralization with concentrated hydro-chloric acid, the solvent was distilled off. Methanol was added to the residue and the crystals thus formed were taken by filtration and thoroughly washed with water to obtain 1.7 g of 3-amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid. Yield: 38%.

後処理

  1. customAn aqueous solution obtained
  2. custom16) obtained in Example 1
  3. temperatureunder reflux for 2 hours
  4. temperatureAfter cooling
  5. distillationthe solvent was distilled off
  6. additionMethanol was added to the residue
  7. customthe crystals thus formed
  8. filtrationwere taken by filtration
  9. washthoroughly washed with water

出典と根拠

ORDレコード
ord-a3579ee4f44d431d939910645b17cdb5
出典データセット
uspto-grants-1994_03
特許番号
US05296603

反応ノート

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