Hydrochloric Acid → 2-Oxo-1,3-thiazolidine-5-carboxylic acid

HRID 487976ノート

反応式

HRID 487976 の反応式
[OH-:1].[Na+].Cl.[NH2:4][CH2:5][CH:6]([S:10][C:11](CC1C=CC=CC=1)=S)[C:7]([OH:9])=[O:8].Cl>C(O)C>[O:1]=[C:11]1[NH:4][CH2:5][CH:6]([C:7]([OH:9])=[O:8])[S:10]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86747702HCID 86747702、化合物

生成物 1

HCID 189610442-Oxo-1,3-thiazolidine-5-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

12.0 ml of a 1 N aqueous solution of sodium hydroxide were added to a suspension of 1.2 g of 3-amino-2-(benzylthiocarbonylthio)propionic acid hydrochloride in 35 ml of ethanol, and the resulting mixture was stirred at room temperature for 30 minutes, after which 12.0 ml of 1 N aqueous hydrochloric acid were added, whilst ice-cooling. The solvent was then removed by distillation under reduced pressure, the resulting residue was dissolved in diethyl ether and the solution was dried over anhydrous magnesium sulfate. The solvent was then removed by distillation under reduced pressure, to give 0.50 g of a colorless powder. This powder was recrystallized from ethyl acetate, to give 0.25 g of the title compound as colorless columnar crystals, melting at 148°-150° C.

後処理

  1. temperaturecooling
  2. customThe solvent was then removed by distillation under reduced pressure
  3. dissolutionthe resulting residue was dissolved in diethyl ether
  4. dry with materialthe solution was dried over anhydrous magnesium sulfate
  5. customThe solvent was then removed by distillation under reduced pressure

出典と根拠

ORDレコード
ord-3e5df2a8b7094439bdbf5641b1aaf4dc
出典データセット
uspto-grants-1994_03
特許番号
US05298516

反応ノート

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