2-Bromobenzyl bromide → 1-Bromo-2-(methoxymethyl)benzene

HRID 488018

反応式

HRID 488018 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[CH3:10][O-:11].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][O:11][CH3:10]

参加物

4

反応物 2

HCID 769652-Bromobenzyl bromideHCID 10942334Sodium Methoxide

生成物 1

HCID 129271621-Bromo-2-(methoxymethyl)benzene

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

685 g (2.74 mol) of o-bromobenzyl bromide was refluxed with 2.74 mol of a 30% strength sodium methylate solution in methanol for 15 hours. After the mixture had cooled to room temperature it was evaporated down, taken up in ethyl acetate, and washed with water. After the organic phase had been dried over sodium sulfate, it was again evaporated down. There was obtained 478.2 g (87%) of the title substance as a colorless liquid.

後処理

  1. customwas evaporated down
  2. washwashed with water
  3. dry with materialAfter the organic phase had been dried over sodium sulfate, it
  4. customwas again evaporated down
  5. customThere was obtained 478.2 g (87%) of the title substance as a colorless liquid

出典と根拠

ORDレコード
ord-c3460ea5355a4863a64497f82519f589
出典データセット
uspto-grants-1994_03
特許番号
US05298527

関連ノート

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