2-Bromobenzyl bromide → 1-Bromo-2-(methoxymethyl)benzene

685 g (2.74 mol) of o-bromobenzyl bromide was refluxed with 2.74 mol of a 30% strength sodium methylate solution in methanol for 15 hours. After the mixture had cooled to room temperature it was evaporated down, taken up in ethyl acetate, and washed with water. After the organic phase had been dried over sodium sulfate, it was again evaporated down. There was obtained 478.2 g (87%) of the title substance as a colorless liquid.

1. customwas evaporated down
2. washwashed with water
3. dry with materialAfter the organic phase had been dried over sodium sulfate, it
4. customwas again evaporated down
5. customThere was obtained 478.2 g (87%) of the title substance as a colorless liquid

ORDレコード

ord-c3460ea5355a4863a64497f82519f589

出典データセット

uspto-grants-1994_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05298527