Sodium Hydroxide → 3-Hydroxy-7,11,15-trimethylhexadeca-6,10,14-trienoic acid

HRID 488152ノート

反応式

HRID 488152 の反応式
[OH:1][CH:2]([CH2:8][CH2:9][CH:10]=[C:11]([CH3:23])[CH2:12][CH2:13][CH:14]=[C:15]([CH3:22])[CH2:16][CH2:17][CH:18]=[C:19]([CH3:21])[CH3:20])[CH2:3][C:4]([O:6]C)=[O:5].[OH-].[Na+]>C(O)C>[OH:1][CH:2]([CH2:8][CH2:9][CH:10]=[C:11]([CH3:23])[CH2:12][CH2:13][CH:14]=[C:15]([CH3:22])[CH2:16][CH2:17][CH:18]=[C:19]([CH3:21])[CH3:20])[CH2:3][C:4]([OH:6])=[O:5]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 53652710Methyl 3-hydroxy-7,11,15-trimethylhexadeca-6,10,14-trienoate

生成物 1

HCID 537523723-Hydroxy-7,11,15-trimethylhexadeca-6,10,14-trienoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of methyl 3-hydroxy-7,11,15-trimethylhexadeca-6,10,14-trienoate (139 mg, 430 μmol), ethanol (1 mL) and sodium hydroxide (1N, 440 μL, 440 μmol) was stirred at room temperature for two hours. The crude mixture was purified by flash chromatography on a 20 mm ID silica gel column. Elution of the column with choloform:acetic acid (40:1/v=v) gave title compound as a colorless gum.

後処理

  1. customThe crude mixture was purified by flash chromatography on a 20 mm ID silica gel column
  2. washElution of the column with choloform

出典と根拠

ORDレコード
ord-38b575bca1d94ac9b544ec23065db09a
出典データセット
uspto-grants-1994_03
特許番号
US05298655

反応ノート

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