Sodium Hydroxide → 3-Nitro-5-(octadecyloxy)benzoic acid

HRID 488273ノート

反応式

HRID 488273 の反応式
C[O:2][C:3](=[O:32])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH:7]=[C:6]([N+:29]([O-:31])=[O:30])[CH:5]=1.[OH-].[Na+]>CO.O1CCOCC1>[N+:29]([C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH:7]=1)[C:3]([OH:32])=[O:2])([O-:31])=[O:30]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 536989543-Nitro-5-(octadecyloxy)benzoic acid methyl ester

生成物 1

HCID 193889433-Nitro-5-(octadecyloxy)benzoic acid収率 62%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of 4.5 g of 3-nitro-5-(octadecyloxy)benzoic acid methyl ester and 4 ml of 6N NaOH in 200 ml of methanol and 50 ml of dioxane was stirred at reflux for 2.5 hours. The solvents were removed at reduced pressure and the residue was acidified with 1N HCl. The solid was filtered and recrystallized from methanol-water to give 2.7 g (62% yield, mp 101°-103°) of 3-nitro-5-(octadecyloxy) benzoic acid.

後処理

  1. temperatureat reflux for 2.5 hours
  2. customThe solvents were removed at reduced pressure
  3. filtrationThe solid was filtered
  4. customrecrystallized from methanol-water

出典と根拠

ORDレコード
ord-6f48a2f28709480da327d0c51a769222
出典データセット
uspto-grants-1994_03
特許番号
US05298652

反応ノート

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