2-Chlorobenzoic Acid → 2-{4-[2-(4-Dibutylamino-phenyl)-ethyl]phenylamino}-benzoic acid

HRID 488492ノート

反応式

HRID 488492 の反応式
Cl[C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C(N[C:16]1([NH:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][CH:25]=2)=[CH:18][CH2:17]1)CCC.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.[Cu].[Cu]Cl>[CH2:10]([N:31]([CH2:32][CH2:33][CH2:34][CH3:35])[C:16]1[CH:17]=[CH:18][C:19]([CH2:22][CH2:23][C:24]2[CH:25]=[CH:26][C:27]([NH:30][C:2]3[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=3[C:4]([OH:6])=[O:5])=[CH:28][CH:29]=2)=[CH:20][CH:21]=1)[CH2:2][CH2:3][CH3:4]

参加物

7

反応物 3

HCID 83742-Chlorobenzoic AcidHCID 11430Potassium CarbonateHCID 86594891HCID 86594891、化合物

生成物 1

HCID 222696822-{4-[2-(4-Dibutylamino-phenyl)-ethyl]phenylamino}-benzoic acid収率 18.6%

試薬・触媒・溶媒 3

HCID 23978Copper触媒HCID 62652Cuprous chloride触媒HCID 6228Dimethylformamide溶媒

実験手順

The title compound was prepared from 2-chlorobenzoic acid (1.46 g, 9.36 mmol), 4-[2-(4,4-dibutylaminophenyl)ethyl]phenylamine (3.31 g, 10.20 mmol), anhydrous potassium carbonate (4.27 g, 30.88 mmol), copper powder (1.25 g, 19.65 mmol), and copper(I) chloride (0.092 g, 0.93 mmol) in dry DMF (30 mL) using the procedure described in Example 1, Step C, Method B. This procedure yielded a 0.39 g (0.87 mmol, 8.6%) of the desired product. mp 115-117° C.

出典と根拠

ORDレコード
ord-e0761f2215a5472dac2c64bded80ab9e
出典データセット
uspto-grants-2005_12
特許番号
US06972287B1

反応ノート

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