2-Chlorobenzoic Acid → 2-{4-[4-(3,4-Dichlorophenyl)butyl]phenylamino}benzoic acid

HRID 488506ノート

反応式

HRID 488506 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl[C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23]([OH:25])=[O:24].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.[Cu].[Cu]Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]([NH:19][C:21]3[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=3[C:23]([OH:25])=[O:24])=[CH:17][CH:18]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

7

反応物 3

HCID 83742-Chlorobenzoic AcidHCID 11430Potassium CarbonateHCID 136560814-[4-(3,4-Dichlorophenyl)butyl]phenylamine

生成物 1

HCID 98664532-{4-[4-(3,4-Dichlorophenyl)butyl]phenylamino}benzoic acid

試薬・触媒・溶媒 3

HCID 23978Copper触媒HCID 62652Cuprous chloride触媒HCID 6228Dimethylformamide溶媒

実験手順

The title compound, mp 98-105° C., was prepared from 4-[4-(3,4-dichlorophenyl)butyl]phenylamine (0.50 g, 1.7 mmol), 2-chlorobenzoic acid (0.24 g, 1.56 mmol), anhydrous potassium carbonate (0.71 g, 5.15 mmol), copper powder (0.21 g, 3.28 mmol), and copper(I) chloride (0.015 g, 0.15 mmol) in dry DMF (5 mL) using the procedure described in Example 1, Step C, Method B.

出典と根拠

ORDレコード
ord-c7238bc1bb924fc29a8d4a27c5bdfef6
出典データセット
uspto-grants-2005_12
特許番号
US06972287B1

反応ノート

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