HCID 22270443、化合物 → HCID 22270357、化合物

HRID 488596ノート

反応式

HRID 488596 の反応式
[N:1]([CH:4]([CH:6]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:7][CH:8]([CH3:10])[CH3:9])[CH3:5])=[N+]=[N-]>CO.Cl.O=[Pt]=O>[NH2:1][CH:4]([CH:6]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH2:7][CH:8]([CH3:10])[CH3:9])[CH3:5]

参加物

5

反応物 1

HCID 22270443HCID 22270443、化合物

生成物 1

HCID 22270357HCID 22270357、化合物

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid触媒HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

To a solution of 32 mg 2-azido-5-methyl-3-phenylhexane in 1 mL MeOH and 2 drops of 1.2 N HCl, 4 mg PtO2 was added and the solution was stirred under H2 atmosphere for 2 h. The reaction was filtered through a pad of CELITE diatomaceous earth and the pad was rinsed with MeOH. The combined filtrate was concentrated to give the desired product. 1H NMR: (500 MHz, CDCl3): δ0.86 (m, 6H), 0.99 (d, 3H), 1.25 (m, 1H), 1.54 (m, 1H), 1.77 (m, 1H), 2.73 (m, 1H), 3.19 (m, 1H), 7.2-7.4 (m, 5H).

後処理

  1. filtrationThe reaction was filtered through a pad of CELITE diatomaceous earth
  2. washthe pad was rinsed with MeOH
  3. concentrationThe combined filtrate was concentrated

出典と根拠

ORDレコード
ord-43cb98a15b3a460d917a3d7038c31727
出典データセット
uspto-grants-2005_12
特許番号
US06972295B2

反応ノート

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