2-Hydroxyisobutyric acid → 2-Methyl-2-(5-(trifluoromethyl)pyridin-2-yloxy)propanoic acid

HRID 488617ノート

反応式

HRID 488617 の反応式
[H-].[Na+].[OH:3][C:4]([CH3:9])([CH3:8])[C:5]([OH:7])=[O:6].Cl[C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][N:12]=1.ClC1C=C(C(F)(F)F)C=CN=1>>[CH3:8][C:4]([O:3][C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][N:12]=1)([CH3:9])[C:5]([OH:7])=[O:6]

参加物

4

反応物 3

HCID 116712-Hydroxyisobutyric acidHCID 24758Sodium hydrideHCID 222705672-Chloro-4-trifluoromethylpyridine 2-chloro-5-trifluoromethylpyridine

生成物 1

HCID 160983422-Methyl-2-(5-(trifluoromethyl)pyridin-2-yloxy)propanoic acid

実験手順

The title compound was prepared following the procedure described in Reference Example 91, Step A with 1.5 extra equivalent of sodium hydride substituting lithium lactate with hydroxyisobutyric acid and 2-chloro-4-trifluoromethylpyridine 2-chloro-5-trifluoromethylpyridine. 1H NMR (500 MHz, CD3OD): δ 8.38 (br, 1H), 7.94 (dd, 1H), 6.93 (d, 1H), 1.69 (s, 6H).

出典と根拠

ORDレコード
ord-1918ce1430c147d0a8409f52921e7cbb
出典データセット
uspto-grants-2005_12
特許番号
US06972295B2

反応ノート

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