methyl (2Z)-2-(acetylamino)-3-(4-amino-3-isopropylphenyl)acrylate → methyl N-acetyl-4-amino-3-isopropylphenylalaninate

HRID 488652ノート

反応式

HRID 488652 の反応式
[C:1]([NH:4]/[C:5](=[CH:10]\[C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[C:13]([CH:18]([CH3:20])[CH3:19])[CH:12]=1)/[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2].[H][H]>C(O)C.[Pd]>[C:1]([NH:4][C@H:5]([C:6]([O:8][CH3:9])=[O:7])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[C:13]([CH:18]([CH3:20])[CH3:19])[CH:12]=1)(=[O:3])[CH3:2]

参加物

5

反応物 2

HCID 86585325methyl (2Z)-2-(acetylamino)-3-(4-amino-3-isopropylphenyl)acrylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 69803103methyl N-acetyl-4-amino-3-isopropylphenylalaninate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

methyl (2Z)-2-(acetylamino)-3-(4-amino-3-isopropylphenyl)acrylate (752 mg, 2.72 mmole) and 10% Pd/C (143 mg) stirred in ethanol (20 mL) under 1 atmosphere of hydrogen for 16 hours. The mixture was filtered through Celite and the filtrate was concentrated under reduced pressure to provide the titled compound.

後処理

  1. filtrationThe mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-40f018eea4dd47d8859cea3850569147
出典データセット
uspto-grants-2005_12
特許番号
US06972340B2

反応ノート

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