methyl N-{[4-({[(benzyloxy)carbonyl]amino}methyl)cyclohexyl]carbonyl}-L-norleucinate → methyl N-{[4-(aminomethyl)cyclohexyl]carbonyl}-L-norleucinate
反応式
C(OC([NH:11][CH2:12][CH:13]1[CH2:18][CH2:17][CH:16]([C:19]([NH:21][C@H:22]([C:27]([O:29][CH3:30])=[O:28])[CH2:23][CH2:24][CH2:25][CH3:26])=[O:20])[CH2:15][CH2:14]1)=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][CH2:12][CH:13]1[CH2:18][CH2:17][CH:16]([C:19]([NH:21][C@H:22]([C:27]([O:29][CH3:30])=[O:28])[CH2:23][CH2:24][CH2:25][CH3:26])=[O:20])[CH2:15][CH2:14]1参加物
4
実験手順
A mixture of methyl N-{[4-({[(benzyloxy)carbonyl]amino}methyl)cyclohexyl]carbonyl}-L-norleucinate (830 mg, 1.98 mmol), 10% palladium on C (0.056 g) in methanol (10 mL) was stirred under an atmosphere of hydrogen for 4 hours. The mixture was filtered through diatomaceous earth and the filter cake washed with methanol (2×15 mL). The combined methanol was concentrated under reduced pressure to provide the titled compound as a colorless solid.