4-[3-Oxo-7-(3-[1,2,3]triazol-1-ylprop-1-ynyl)-2H-6-azaisoquinolin-2-ylmethyl]benzoic acid tert-butyl ester → 4-[3-Oxo-7-(3-[1,2,3]triazol-1-ylprop-1-ynyl)-2H-6-azaisoquinolin-2-ylmethyl]benzoic acid

HRID 488789ノート

反応式

HRID 488789 の反応式
C([O:5][C:6](=[O:33])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][N:14]2[C:23](=[O:24])[CH:22]=[C:21]3[C:16]([CH:17]=[C:18]([C:25]#[C:26][CH2:27][N:28]4[CH:32]=[CH:31][N:30]=[N:29]4)[N:19]=[CH:20]3)=[CH:15]2)=[CH:9][CH:8]=1)(C)(C)C>FC(F)(F)C(O)=O>[O:24]=[C:23]1[CH:22]=[C:21]2[C:16]([CH:17]=[C:18]([C:25]#[C:26][CH2:27][N:28]3[CH:32]=[CH:31][N:30]=[N:29]3)[N:19]=[CH:20]2)=[CH:15][N:14]1[CH2:13][C:10]1[CH:9]=[CH:8][C:7]([C:6]([OH:33])=[O:5])=[CH:12][CH:11]=1

参加物

3

反応物 1

HCID 697332714-[3-Oxo-7-(3-[1,2,3]triazol-1-ylprop-1-ynyl)-2H-6-azaisoquinolin-2-ylmethyl]benzoic acid tert-butyl ester

生成物 1

HCID 222682364-[3-Oxo-7-(3-[1,2,3]triazol-1-ylprop-1-ynyl)-2H-6-azaisoquinolin-2-ylmethyl]benzoic acid

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 4-[3-oxo-7-(3-[1,2,3]triazol-1-ylprop-1-ynyl)-2H-6-azaisoquinolin-2-ylmethyl]benzoic acid tert-butyl ester (0.29 g, 0.66 mmol, Example 14A) is treated with trifluoroacetic acid (10 mL) and stirred at room temperature for 40 minutes. The reaction mixture is evaporated to dryness, triturated with ethyl acetate, the solid collect by filtration, washed with water, washed with ethyl acetate, and dried under house vacuum. This will afford the desired product.

後処理

  1. customThe reaction mixture is evaporated to dryness
  2. customtriturated with ethyl acetate
  3. filtrationthe solid collect by filtration
  4. washwashed with water
  5. washwashed with ethyl acetate
  6. customdried under house vacuum

出典と根拠

ORDレコード
ord-1fd0a09435054f63a0a97de8e74a9286
出典データセット
uspto-grants-2005_12
特許番号
US06974822B2

反応ノート

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