Diisopropylethylamine → HCID 72976879、化合物
反応式
[CH:1](N(CC)C(C)C)([CH3:3])[CH3:2].[F:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]2[CH2:19][CH:18]2[NH:20][C:21]2[C:22]3[N:36]=[N:35][N:34]([CH:37]4[CH2:41][CH:40]([CH2:42][OH:43])[CH:39]([OH:44])[CH:38]4[OH:45])[C:23]=3[N:24]=[C:25]([S:27][CH2:28][CH2:29][C:30](F)(F)F)[N:26]=2)=[CH:13][CH:12]=1>ClCCl>[F:10][C:11]1[CH:12]=[CH:13][C:14]([CH:17]2[CH2:19][CH:18]2[NH:20][C:21]2[C:22]3[N:36]=[N:35][N:34]([CH:37]4[CH:38]5[O:45][C:1]([CH3:3])([CH3:2])[O:44][CH:39]5[CH:40]([CH2:42][OH:43])[CH2:41]4)[C:23]=3[N:24]=[C:25]([S:27][CH2:28][CH2:29][CH3:30])[N:26]=2)=[CH:15][CH:16]=1参加物
4
実験手順
N,N-Diisopropylethylamine (1.29 g) was added to a solution of [3aR-(3aα,4α,6α,6aα)]-6-[7-chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-methanol (prepared as described in International Patent Application WO 9703084) (1.0 g) and the product of step d) (0.75 g) in dichloromethane (25 ml). The reaction mixture was stirred at room temperature for 3 hours, then washed with water, dried and evaporated. The residue was purified (SiO2, ethyl acetate:isohexane 1:1 as eluent) to afford the subtitle compound (1.25 g).