4-[1-oxo-7-(3-[1,2,4]Triazol-1-ylprop-1-ynyl)-1H-3,5,8-triazaisoquinolin-2-ylmethyl]benzoic Acid tert-Butyl Ester → 4-[1-oxo-7-(3-[1,2,4]Triazol-1-ylprop-1-ynyl)-1H-3,5,8-triazaisoquinolin-2-ylmethyl]benzoic Acid

HRID 489190ノート

反応式

HRID 489190 の反応式
C([O:5][C:6](=[O:33])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][N:14]2[N:23]=[CH:22][C:21]3[C:16](=[N:17][C:18]([C:24]#[C:25][CH2:26][N:27]4[CH:31]=[N:30][CH:29]=[N:28]4)=[CH:19][N:20]=3)[C:15]2=[O:32])=[CH:9][CH:8]=1)(C)(C)C>FC(F)(F)C(O)=O>[O:32]=[C:15]1[C:16]2[C:21](=[N:20][CH:19]=[C:18]([C:24]#[C:25][CH2:26][N:27]3[CH:31]=[N:30][CH:29]=[N:28]3)[N:17]=2)[CH:22]=[N:23][N:14]1[CH2:13][C:10]1[CH:11]=[CH:12][C:7]([C:6]([OH:33])=[O:5])=[CH:8][CH:9]=1

参加物

3

反応物 1

HCID 104111454-[1-oxo-7-(3-[1,2,4]Triazol-1-ylprop-1-ynyl)-1H-3,5,8-triazaisoquinolin-2-ylmethyl]benzoic Acid tert-Butyl Ester

生成物 1

HCID 222652984-[1-oxo-7-(3-[1,2,4]Triazol-1-ylprop-1-ynyl)-1H-3,5,8-triazaisoquinolin-2-ylmethyl]benzoic Acid

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 4-[1-oxo-7-(3-[1,2,4]triazol-1-ylprop-1-ynyl)-1H-3,5,8-triazaisoquinolin-2-ylmethyl]benzoic acid tert-butyl ester (0.46 g, 1.04 mmol, Example 15A) is treated with trifluoroacetic acid (10 mL) and stirred at room temperature for 40 minutes. The reaction mixture is evaporated to dryness, triturated with ethyl acetate, the solid is collected by filtration, washed with water, washed with ethyl acetate, and dried under house vacuum. This will afford the desired product.

後処理

  1. customThe reaction mixture is evaporated to dryness
  2. customtriturated with ethyl acetate
  3. filtrationthe solid is collected by filtration
  4. washwashed with water
  5. washwashed with ethyl acetate
  6. customdried under house vacuum

出典と根拠

ORDレコード
ord-2cc3e9b88c184c3c9dd6dbd5d9b44078
出典データセット
uspto-grants-2005_12
特許番号
US06977261B2

反応ノート

読み込み中…