Hydrochloric Acid → 1,2-Benzisothiazole-3-carboxylic acid

HRID 48990

反応式

HRID 48990 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([C:10](N)=[O:11])=[N:2]1.[OH-:13].[Na+].Cl>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([C:10]([OH:11])=[O:13])=[N:2]1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 156394701,2-Benzothiazole-3-carboxamide

生成物 1

HCID 945121,2-Benzisothiazole-3-carboxylic acid収率 96%

実験手順

A mixture of 1,2-benzisothiazole-3-carboxamide (5.0 g, 0.028 mole) and 1N aqueous sodium hydroxide (55 ml) is heated on a steam bath until solution is achieved (approximately 30 minutes), cooled to room temperature, and acidified with 2N hydrochloric acid. The resulting precipitate is filtered and dried in vacuo to afford the title compound (1.85 g, 96%) as a white solid, which is identified by NMR and IR spectral analysis.

後処理

  1. temperatureis heated on a steam bath until solution
  2. custom(approximately 30 minutes)
  3. filtrationThe resulting precipitate is filtered
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-799d51a894f9464c914a010d58fc72da
出典データセット
uspto-grants-2004_03
特許番号
US06706663B2

関連ノート

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