Phosphorus oxychloride → 3-(5-Methyl-1,3,4-oxadiazol-2-yl)-5-nitro-1,2-benzisothiazole
反応式
[C:1]([NH:4][NH:5][C:6]([C:8]1[C:12]2[CH:13]=[C:14]([N+:17]([O-:19])=[O:18])[CH:15]=[CH:16][C:11]=2[S:10][N:9]=1)=[O:7])(=O)[CH3:2].P(Cl)(Cl)(Cl)=O>C(#N)C>[CH3:2][C:1]1[O:7][C:6]([C:8]2[C:12]3[CH:13]=[C:14]([N+:17]([O-:19])=[O:18])[CH:15]=[CH:16][C:11]=3[S:10][N:9]=2)=[N:5][N:4]=1参加物
4
実験手順
To a mixture of 1-acetyl-2-[(5-nitro-1,2-benzisothiazol-3-yl)carbonyl]hydrazine(4.55 g, 0.0163 mol) and acetonitrile at room temperature is added phosphorous oxychloride (14.9 g, 0.0972 mol). The resultant mixture is heated to reflux, stirred two hours, cooled to room temperature and filtered to afford the title compound as an off-white solid (mp>250° C.) which is identified by NMR spectral analysis.
後処理
- temperatureto reflux
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-d8795f9d47814055bb529fdb58344c03
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06706663B2
反応ノート
読み込み中…