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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
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m-Chloroperbenzoic acid → 1-Methyl-3-[3-[4-[(methylsulfinyl)methyl]-1,3-dioxolan-2-yl]-1,2-benzisothiazol-5-yl]-6-(trifluoromethyl)uracil

HRID 49007
ノート
印刷プレビュー

反応式

HRID 49007 の反応式
[CH3:1][N:2]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][C:6](=[O:7])[N:5]([C:14]2[CH:15]=[CH:16][C:17]3[S:21][N:20]=[C:19]([CH:22]4[O:26][CH:25]([CH2:27][S:28][CH3:29])[CH2:24][O:23]4)[C:18]=3[CH:30]=2)[C:3]1=[O:4].ClC1C=CC=C(C(OO)=[O:39])C=1>C(Cl)Cl>[CH3:1][N:2]1[C:9]([C:10]([F:11])([F:12])[F:13])=[CH:8][C:6](=[O:7])[N:5]([C:14]2[CH:15]=[CH:16][C:17]3[S:21][N:20]=[C:19]([CH:22]4[O:26][CH:25]([CH2:27][S:28]([CH3:29])=[O:39])[CH2:24][O:23]4)[C:18]=3[CH:30]=2)[C:3]1=[O:4]
参加物実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 206341881-Methyl-3-[3-[4-[(methylthio)methyl]-1,3-dioxolan-2-yl]-1,2-benzisothiazol-5-yl]-6-(trifluoromethyl)uracil

生成物 1

HCID 206341861-Methyl-3-[3-[4-[(methylsulfinyl)methyl]-1,3-dioxolan-2-yl]-1,2-benzisothiazol-5-yl]-6-(trifluoromethyl)uracil収率 70%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 1-methyl-3-[3-[4-[(methylthio)methyl]-1,3-dioxolan-2-yl]-1,2-benzisothiazol-5-yl]-6-(trifluoromethyl)uracil (0.970 g, 21.1 mmol), m-chloroperbenzoic acid (72%, 0.500 g, 21.1 mmol) and methylene chloride is stirred one hour at room temperature and concentrated in vacuo. The residue is taken up in ethyl acetate and washed twice with 5% aqueous sodium carbonate and once with brine. The organic layer is dried over anhydrous magnesium sulfate and concentrated in vacuo to a white solid, which is chromatographed on silica gel with ethanol-ethyl acetate to afford the title compound as a white solid (0.700 g, 70.0%, mp 72-75° C.) which is identified by IR and NMR spectral analysis.

後処理

  1. concentrationconcentrated in vacuo
  2. washwashed twice with 5% aqueous sodium carbonate and once with brine
  3. dry with materialThe organic layer is dried over anhydrous magnesium sulfate
  4. concentrationconcentrated in vacuo to a white solid, which
  5. customis chromatographed on silica gel with ethanol-ethyl acetate

出典と根拠

ORDレコード
ord-0b135d08b5714e00b017489d0509413a
出典データセット
uspto-grants-2004_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06706663B2

反応ノート

読み込み中…

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