1-Ethyl-4-(5-nitropyridin-2-yl)piperazine → 6-(4-Ethylpiperazin-1-yl)pyridin-3-amine
反応式
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][N:10]=2)[CH2:5][CH2:4]1)[CH3:2].[H][H]>CO.[Pd]>[CH2:1]([N:3]1[CH2:4][CH2:5][N:6]([C:9]2[N:10]=[CH:11][C:12]([NH2:15])=[CH:13][CH:14]=2)[CH2:7][CH2:8]1)[CH3:2]参加物
5
実験手順
A mixture of 2.47 g (10 mmol) 1-ethyl-4-(5-nitro-pyridin-2-yl)-piperazine and 0.247 g Pd/C (10%) in 25 ml methanol was treated with 1 bar hydrogen at room temperature for 2 h. After filtration the mixture was evaporated to dryness to yield 2.12 g (98%) of the title compound as colorless solid. (m/e): 207.3 (MH+; 100%).
後処理
- filtrationAfter filtration the mixture
- customwas evaporated to dryness
出典と根拠
- ORDレコード
- ord-a1e7d8f893064257afae504bc759d0f1
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07528135B2
反応ノート
読み込み中…