Dimethylmaleic anhydride → 2-chloro-5-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzenesulfonamide

HRID 4901

反応式

HRID 4901 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:12])=[C:6]([S:8]([NH2:11])(=[O:10])=[O:9])[CH:7]=1.[CH3:13][C:14]1[C:15]([O:17][C:18](=O)[C:19]=1[CH3:20])=[O:16]>N1C=CC=CC=1>[Cl:12][C:5]1[CH:4]=[CH:3][C:2]([N:1]2[C:15](=[O:16])[C:14]([CH3:13])=[C:19]([CH3:20])[C:18]2=[O:17])=[CH:7][C:6]=1[S:8]([NH2:11])(=[O:9])=[O:10]

参加物

4

反応物 2

HCID 13010Dimethylmaleic anhydrideHCID 748345-Amino-2-chlorobenzenesulfonamide

生成物 1

HCID 148372102-chloro-5-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzenesulfonamide収率 93%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

In 3 ml of pyridine, 1 mmol of 5-amino-2-chlorobenzenesulfonamide and 1.05 mmol of 2,3-dimethylmaleic anhydride were stirred at 90-100° C. for 9 hours. Pyridine was then distilled off from the reaction mixture, followed by the addition of 20 ml of ice water and 0.1 ml of 35% hydrochloric acid to the solid residue. After the mixture thus formed was stirred for 20 minutes, the resulting precipitate was collected by filtration and then dried in air. Yield: 93%. Its physicochemical properties are shown in Table 8.

後処理

  1. distillationPyridine was then distilled off from the reaction mixture
  2. additionfollowed by the addition of 20 ml of ice water and 0.1 ml of 35% hydrochloric acid to the solid residue
  3. customAfter the mixture thus formed
  4. filtrationthe resulting precipitate was collected by filtration
  5. customdried in air

出典と根拠

ORDレコード
ord-0486b163d93d4c4098549fecca2a4eab
出典データセット
uspto-grants-1993_09
特許番号
US05242894

関連ノート

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