Triethylamine → HCID 57674748、化合物

HRID 490224ノート

反応式

HRID 490224 の反応式
C(O[CH:4]=[C:5]([C:8]#[N:9])[C:6]#[N:7])C.Cl.[NH2:11][CH2:12][CH2:13][NH:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1)=[O:16].C(N(CC)CC)C>C(#N)C>[C:6]([C:5]([C:8]#[N:9])=[CH:4][NH:11][CH2:12][CH2:13][NH:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1)=[O:16])#[N:7]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 671522-(Ethoxymethylene)propanedinitrileHCID 23033068N-(2-aminoethyl)-4-fluorobenzamide hydrochloride

生成物 1

HCID 57674748HCID 57674748、化合物収率 68.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

実験手順

After adding acetonitrile (100 mL) and ethoxymethylenemalononitrile (4.5 g) to N-(2-aminoethyl)(4-fluorophenyl)carboxamide hydrochloride (8.3 g), a solution of triethylamine (4.5 g) in acetonitrile (20 mL) was added thereto. After stirring at room temperature for 15 minutes, the solvent was distilled off under reduced pressure, water and ethyl acetate were added to the residue, and the mixture was stirred. The precipitated solid was filtered out to obtain the crude title compound (6.5 g) as a brown solid.

後処理

  1. distillationthe solvent was distilled off under reduced pressure, water and ethyl acetate
  2. additionwere added to the residue
  3. stirringthe mixture was stirred
  4. filtrationThe precipitated solid was filtered out

出典と根拠

ORDレコード
ord-7113afc0302347c893befd036be00967
出典データセット
uspto-grants-2009_05
特許番号
US07528140B2

反応ノート

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