1-Benzyl-4-(N-Boc-amino)piperidine → 4-(N-Boc-amino)piperidine

HRID 490295ノート

反応式

HRID 490295 の反応式
[C:1]([O:5][C:6](=[O:21])[NH:7][CH:8]1[CH2:13][CH2:12][N:11](CC2C=CC=CC=2)[CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6](=[O:21])[NH:7][CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 1

HCID 44386181-Benzyl-4-(N-Boc-amino)piperidine

生成物 1

HCID 7238334-(N-Boc-amino)piperidine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of D6 (10 g, 3.4 mmol) in methanol (150 ml) was hydrogenated at 50 psi in a Parr hydrogenator using 10% Palladium on carbon catalyst (800 mg) for 18 h. Catalyst was filtered off and the filtrate concentrated under reduced pressure to afford the product as a white solid.

後処理

  1. customfor 18 h
  2. filtrationCatalyst was filtered off
  3. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-791ab8199bb048bbb535676d6d60f300
出典データセット
uspto-grants-2009_05
特許番号
US07528151B2

反応ノート

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