6-nitro-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate → 6-Amino-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate

HRID 490310ノート

反応式

HRID 490310 の反応式
[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]2[C:19]3[C:14](=[CH:15][C:16]([N+:20]([O-])=O)=[CH:17][CH:18]=3)[NH:13][N:12]=2)=[O:9])[CH2:4][CH2:3]1>C(O)C.[Pd]>[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]2[C:19]3[C:14](=[CH:15][C:16]([NH2:20])=[CH:17][CH:18]=3)[NH:13][N:12]=2)=[O:9])[CH2:4][CH2:3]1

参加物

4

反応物 1

HCID 670827616-nitro-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate

生成物 1

HCID 115073446-Amino-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

30 mg (0.1 mmol) of 6-nitro-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate (Example 5B) in 15 ml of ethanol were hydrogenated in the presence of 10% palladium/carbon under a hydrogen pressure of 2 bar at room temperature for 2.5 h. The catalyst was filtered off with suction, and the filtrate was concentrated. Yield: 21 mg (76%), M+H+: 275.2.

後処理

  1. customat room temperature
  2. customfor 2.5 h
  3. filtrationThe catalyst was filtered off with suction
  4. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-3e775771a57d40f68ffd3f8c572af320
出典データセット
uspto-grants-2009_05
特許番号
US07528155B2

反応ノート

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