5-Benzyl-octahydropyrrolo(3,4-c)pyrrole-1,3-dione → Perhydropyrrolo(3,4-c)pyrrole-1,3-dione

HRID 490471

反応式

HRID 490471 の反応式
C([N:8]1[CH2:12][CH:11]2[C:13](=[O:17])[NH:14][C:15](=[O:16])[CH:10]2[CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[C:13]1(=[O:17])[CH:11]2[CH2:12][NH:8][CH2:9][CH:10]2[C:15](=[O:16])[NH:14]1

参加物

4

反応物 1

HCID 45649025-Benzyl-octahydropyrrolo(3,4-c)pyrrole-1,3-dione

生成物 1

HCID 21476587Perhydropyrrolo(3,4-c)pyrrole-1,3-dione

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution 5-benzyl-tetrahydropyrrolo[3,4-c]pyrrole-1,3-dione, (11.5 g; 49.9 mmol) in ethanol (200 ml) is placed in a 1000 ml autoclave and palladium-on-charcoal (5%; 2 g; 0.9 mmol) is then added. After having purged the reactor with nitrogen, the autoclave is placed under 58 bars of hydrogen at 70° C. for 16 hours. After returning to 20° C., filtration and washing of the catalyst, evaporation is carried out under reduced pressure and the solid obtained is then recrystallized from methanol (100 ml) and drying is carried out under reduced pressure at constant weight. Perhydropyrrolo[3,4-c]pyrrole-1,3-dione, (3.6 g) is isolated, the characteristics of which are as follows:

後処理

  1. additionis then added
  2. customAfter having purged the reactor with nitrogen
  3. customAfter returning to 20° C.
  4. filtrationfiltration
  5. washwashing of the catalyst, evaporation
  6. customthe solid obtained
  7. customis then recrystallized from methanol (100 ml)
  8. customdrying

出典と根拠

ORDレコード
ord-3c9ae7d963e149698ed2d87e386aa416
出典データセット
uspto-grants-2009_05
特許番号
US07528147B2

関連ノート

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