[5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol → 5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde

HRID 49054

反応式

HRID 49054 の反応式
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11]([CH2:16][OH:17])=[CH:10]2)[CH3:2]>ClCCl.[O-2].[Mn+2]>[CH2:18]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11]([CH:16]=[O:17])=[CH:10]2)[CH3:19]

参加物

4

反応物 1

HCID 22042151[5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol

生成物 1

HCID 220421145-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde収率 86.1%

試薬・触媒・溶媒 2

HCID 160959Manganese oxide触媒HCID 6344Dichloromethane溶媒

実験手順

Manganese oxide (3.75 g, 43.1 mmol) was added portionwise to [5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol (660 mg, 2.53 mmol) dissolved in dichloromethane (68 mL) under nitrogen at room temperature. The precipitate was filtered through celite, washing with hot dichloromethane. The filtrate was concentrated to give 563 mg (83%) of 5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde as a waxy brown solid.

後処理

  1. filtrationThe precipitate was filtered through celite
  2. washwashing with hot dichloromethane
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-d60fafba983a46b6afe1da41a9ce5d74
出典データセット
uspto-grants-2004_03
特許番号
US06706709B2

関連ノート

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