1-Benzyl-5-nitro-1,2-dihydro-3h-indazol-3-one → HCID 68730847、化合物

HRID 490552ノート

反応式

HRID 490552 の反応式
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([N+:17]([O-])=O)=[CH:14][CH:15]=2)[C:10](=[O:20])[NH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[Pd]>[NH2:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[N:8]([CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[NH:9][C:10]2=[O:20]

参加物

4

反応物 1

HCID 3849951-Benzyl-5-nitro-1,2-dihydro-3h-indazol-3-one

生成物 1

HCID 68730847HCID 68730847、化合物収率 99.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 1-benzyl-5-nitro-1,2-dihydro-indazol-3-one (0.44 g) in MeOH (50 mL) was added Pd/C(10%) catalyst (0.1 g) and the reaction mixture was stirred for four hours at ambient temperature under a hydrogen atmosphere using a balloon. After this time the reaction mixture was filtered through Celite® which was washed with more EtOAc. The combined organic solution was evaporated in vacuo for afford the desired 5-amino-1-benzyl-1,2-dihydro-indazol-3-one (0.39 g) which was taken into the next reaction without further purification. MS (ESI+): 240.1 ([M+H]+).

後処理

  1. filtrationAfter this time the reaction mixture was filtered through Celite® which
  2. washwas washed with more EtOAc
  3. customThe combined organic solution was evaporated in vacuo

出典と根拠

ORDレコード
ord-a94f0d8804e84c1ca686bc7032f4d9e9
出典データセット
uspto-grants-2009_05
特許番号
US07528158B2

反応ノート

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