HCID 68838102、化合物 → HCID 68835059、化合物
反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][CH2:14][C:15]#[N:16])[NH:8][C:7]2=[O:17])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][CH2:14][C:15]#[N:16])[NH:8][C:7]2=[O:17]参加物
4
実験手順
To a solution of 3-(5-Nitro-3-oxo-2,3-dihydro-indazol-1-yl)-propionitrile (0.521 g) in MeOH (50 mL) was added Pd/C(10%) catalyst (0.13 g) and the reaction mixture was stirred for 20 hours at ambient temperature under a hydrogen atmosphere using a balloon. After this time the reaction mixture was filtered through Celite® which was washed with more EtOAc. The combined organic solution was evaporated in vacuo for afford the desired 3-(5-amino-3-oxo-2,3-dihydro-indazol-1-yl)-propionitrile (0.45 g) which was taken into the next reaction without further purification. MS (ESI+): 203.4 ([M+H]+).