関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 6-(benzyloxy)-1H-indole | HCID 260804 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | (6-Benzyloxy-1H-indol-3-yl)-oxo-acetic acid methyl ester | HCID 34181007 | — |
反応手順
To a solution of 6-benzoxyindole (1.05 g, 4.7 mmol) in ether (8 mL) is added oxalyl chloride (0.45 mL) at 0˜5° C., stirred for 2 hrs. The reaction mixture is cooled to −78° C., sodium methoxide (25% w/w in methanol, 2.4 mL) is added, warmed up to room temperature, quenched by water. Solid product is collected by filtration, washed by water and dried under vacuum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07528160B2 |
|---|
| 出典データセット | uspto-grants-2009_05 |
|---|
| ORD ID | ord-9f2f750735574ac29f41f169be20f3aa |
|---|
| 出典メモ | uspto-grants-2009_05 |
|---|
