反应详情

温度

-78 °C

To a solution of 6-benzoxyindole (1.05 g, 4.7 mmol) in ether (8 mL) is added oxalyl chloride (0.45 mL) at 0˜5° C., stirred for 2 hrs. The reaction mixture is cooled to −78° C., sodium methoxide (25% w/w in methanol, 2.4 mL) is added, warmed up to room temperature, quenched by water. Solid product is collected by filtration, washed by water and dried under vacuum.

1. temperaturewarmed up to room temperature
2. customquenched by water
3. filtrationSolid product is collected by filtration
4. washwashed by water
5. customdried under vacuum