3-(4-Methoxy-2-nitrophenyl)acrylic acid methyl ester → 7-Methoxy-3,4-dihydroquinolin-2(1H)-one
反応式
C[O:2][C:3](=O)[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:7]=1[N+:14]([O-])=O>CO.CCOC(C)=O.CCO.[Pd]>[CH3:13][O:12][C:9]1[CH:8]=[C:7]2[C:6]([CH2:5][CH2:4][C:3](=[O:2])[NH:14]2)=[CH:11][CH:10]=1参加物
6
実験手順
A solution of 3-(4-methoxy-2-nitro-phenyl)-acrylic acid methyl ester (4.00 g, 16.9 mmol) in MeOH (100 mL) and EtOAc (20 mL) is added a slurry of Pd/C (200 mg) in EtOH (20 mL). The suspension is hydrogenated under a pressure of 60 psi for 12 hours. The mixture is then filter through a pad of celite and the filtrate is concentrated and purified on silica gel chromatography column with 30-40-50% EtOAc/Hexanes to obtain the title product (1.30 g, 43%) and an uncyclized by-product (0.60 g).
後処理
- filtrationThe mixture is then filter through a pad of celite
- concentrationthe filtrate is concentrated
- custompurified on silica gel chromatography column with 30-40-50% EtOAc/Hexanes
出典と根拠
- ORDレコード
- ord-ba24b49f2b9643df8e7baaf775c09c06
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07528160B2
反応ノート
読み込み中…