phenylalaninol, (R)- → 1-Ethyl-N-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]-4-(tetrahydro-2H-pyran 4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

HRID 490895

反応式

HRID 490895 の反応式
[CH2:1]([N:3]1[C:7]2=[N:8][CH:9]=[C:10]([C:19]([OH:21])=O)[C:11]([NH:12][CH:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[C:6]2[CH:5]=[N:4]1)[CH3:2].[NH2:22][C@H:23]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:24][OH:25].C(N1C2=NC=C(C(N[C@H](C3C=CC=CC=3)CO)=O)C(NC3CCOCC3)=C2C=N1)C>>[CH2:1]([N:3]1[C:7]2=[N:8][CH:9]=[C:10]([C:19]([NH:22][C@H:23]([CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH2:24][OH:25])=[O:21])[C:11]([NH:12][CH:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)=[C:6]2[CH:5]=[N:4]1)[CH3:2]

参加物

4

反応物 3

HCID 853475phenylalaninol, (R)-HCID 112812951-Ethyl-N-[(1R)-2-hydroxy-1-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideHCID 534878291-Ethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

生成物 1

HCID 576752241-Ethyl-N-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]-4-(tetrahydro-2H-pyran 4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

実験手順

Intermediate 45 was prepared from Intermediate 17 and (2R)-2-amino-3-phenyl-1-propanol (commercially available from Aldrich) using an analagous method to that for Intermediate 42. LCMS showed MH+=424; TRET=2.59 min.

後処理

  1. customTRET=2.59 min.

出典と根拠

ORDレコード
ord-0b1b452c082740d29ac3d49a51d0c15e
出典データセット
uspto-grants-2009_05
特許番号
US07528148B2

関連ノート

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