Sodium Hydroxide → HCID 57675146、化合物
反応式
[OH-].[Na+].[CH2:3]([N:5]1[C:9]2=[N:10][CH:11]=[C:12]([C:22]([O:24]CC)=[O:23])[C:13]([N:14]([CH3:21])[CH:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[C:8]2[CH:7]=[N:6]1)[CH3:4]>C(O)C>[CH2:3]([N:5]1[C:9]2=[N:10][CH:11]=[C:12]([C:22]([OH:24])=[O:23])[C:13]([N:14]([CH3:21])[CH:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[C:8]2[CH:7]=[N:6]1)[CH3:4]参加物
4
反応条件
- 温度
- 50 °C
実験手順
Sodium hydroxide (0.43 g, 10.8 mmol) was added to a solution of Intermediate 51 in ethanol (10 ml, 95%). The reaction mixture was heated at 50° C. for 18 hours. The solvent was evaporated in vacuo and the residue dissolved in water and acidified to pH 3 by the addition of aqueous hydrochloric acid. The solution was extracted with DCM. The organic phase was separated using a hydrophobic frit (Whatman PTFE Folter Media with Polypropylene Housing 5 μM pore size) and the solvent evaporated in vacuo to give Intermediate 52 as a white solid (0.65 g). LCMS showed MH+=305; TRET=1.97 min.