3-Fluorophenol → 3-(3-Fluorophenoxy)propanoic acid
反応式
[F:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH2:10][CH2:11][C:12]([OH:14])=[O:13].[OH-].[Na+]>O>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[O:8][CH2:10][CH2:11][C:12]([OH:14])=[O:13]参加物
5
実験手順
3-Fluorophenol (8.9 g, 79.5 mmol) and 3-bromopropionic acid (12.24 g, 80.0 mmol) were placed in a flask. A solution of NaOH (6.7 g, 167 mmol) in 20 mL water was added slowly to the flask. The reaction mixture was heated to reflux for two hours and then cooled to room temperature and partitioned between ethyl acetate and water. The organic layer was dried over MgSO4, and solvent was evaporated under reduced pressure to give 4.57 g (25 mmol, 31.4%) of 3-(3-fluoro-phenoxy)-propionic acid. MS: 185 (M+H)+.
後処理
- temperatureThe reaction mixture was heated
- temperatureto reflux for two hours
- custompartitioned between ethyl acetate and water
- dry with materialThe organic layer was dried over MgSO4, and solvent
- customwas evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-8e3df580c6a841e6a6a0593fac2ce51a
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07528250B2
反応ノート
読み込み中…