Hydrochloric Acid → Methyl 4-Iodophenylacetate

HRID 490989

反応式

HRID 490989 の反応式
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.Cl.[CH3:13]O>O1CCOCC1>[I:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:13])=[O:10])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1372144-Iodophenylacetic acid

生成物 1

HCID 10378700Methyl 4-Iodophenylacetate収率 98%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a stirred solution of 4-iodophenylacetic acid (5.0 g, 19.1 mmol) in MeOH (200 mL) was added 4N hydrochloric acid in dioxane (10 mL). The reaction mixture was stirred for 24 h at room temperature and then the solvent was removed under reduced pressure to give the title compound (5.17 g, 98% yield), which was used without further purification.

後処理

  1. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-15ce9d6f095f4c6ebd484d396d6f8dd3
出典データセット
uspto-grants-2009_05
特許番号
US07528253B2

関連ノート

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