Acetyl chloride → 2'-Iodoacetanilide

HRID 491027ノート

反応式

HRID 491027 の反応式
[I:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:9](Cl)(=[O:11])[CH3:10]>N1C=CC=CC=1.Cl>[I:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:9](=[O:11])[CH3:10]

参加物

5

反応物 2

HCID 6367Acetyl chlorideHCID 119952-Iodoaniline

生成物 1

HCID 1405592'-Iodoacetanilide

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 1049Pyridine溶媒

反応条件

温度
0 °C

実験手順

2-Iodoaniline (1.00 g, 4.56 mmol) was dissolved in pyridine (5 mL) and cooled to 0° C. After acetyl chloride (314 μL, 5.94 mmol) was added, the reaction was stirred at 0° C. for 1 hour and then at room temperature for 2 hours. The reaction was diluted with 1 N HCl and extracted with ether. The organic layer was dried (MgSO4) and concentrated to give the desired acetamide (assumed quantitative), which was used in the next reaction without further purification.

後処理

  1. waitat room temperature for 2 hours
  2. extractionextracted with ether
  3. dry with materialThe organic layer was dried (MgSO4)
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-b315f9eac74f422d83fa6252ec00be08
出典データセット
uspto-grants-2009_05
特許番号
US07528262B2

反応ノート

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